Venus Talk follows three female friends who are all in their 40’s.
Shin-Hye (Uhm Jung-Hwa) works as a producer for a cable TV station and she is still single. She hears that Director Lee (Choi Moo-Sung) will marry her junior colleague who is only 26-years-old. Shin-Hye gets pissed, because they dated for 6 years and she even supported him before his promotion to a director. Shin-Hye and some of her co-workers meet afterwork for drinks. A loud argument takes place with everybody but Shin-Hye and her younger colleague Hyun-Seung (Lee Jae-Yoon) left to drink alone. They end up spending the night at a motel. Shin-Hye looks back at that night as a one night stand, but Hyun-Seung thinks about it differently.
Mi-Yeon (Moon So-Ri) is a housewife who at first seems content with her life. Before she married Jae-Ho (Lee Sung-Min), she stipulated that they should have sex 3 times a week. Jae-Ho finds it harder and harder to satisfy his wife. One day, Mi-Yeon finds something hidden in Jae-Ho’s desk.